In this article 4 web based and 4 Desktop feed readers are compared. Am using FeedDaemon for more than one year and am satisfied with it. The latest version which is in Beta now (release candidate 3) allows you to synchronies with Google reader too.
Web based feed readers compared are Google Reader, Bloglines , NewsGator Online and Netvibes
Desktop feed readers compared are Blogbridge, FeedDemon, RSSOwl, Feedreader
Read the comparison here